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Transportation condition&recommended shipping method: by air, by sea or by express Storage condition: 2-8°C Minimum Order Qty: Negotiation Certification: COA, HPLC, GC, HNMR, Assay, Water Content(K.F), TLC availablePropanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)-; (S)-3-(tert-Butyloxycarbonylamino)-2-hydroxypropionic acid; (2S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-propanoic acid; 3-tert-ButoxycarbonylaMino-(S)-2-hydroxy-propionic acid; Boc-(S)-isoserine; (S)-3-(Boc-aMino)-2-hydroxy-propanoic acid; (S)-3-((tert-Butoxycarbonyl)aMino)-2-hydroxypropanoic acid; (2S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acidThey are usually used to pack powder. And they can prevent sunshine and water from getting bad.The hard carton can protect your products from crashing and getting wet.(S)-isoserine 15a (21 g, 0.20 mol) was dissolved in tetrahydrofuran (100 mL)And a mixed solvent of 10percent aqueous sodium hydroxide solution (100 mL),Di-tert-butyl dicarbonate (50 mL, 0.22 mol) was added dropwise.The reaction was carried out at room temperature for 9 hours.The aqueous phase was adjusted to pH 2 with 4 mol/L hydrochloric acid, and extracted with dichloromethane/methanol (v/v = 5/1, 50 mL × 3) and dried over anhydrous sodium sulfate.Filter by suction, concentrate under reduced pressure,The title compound 15b was obtained as a colorless oil (35 g, yield: 85percent). To a stirring solution of S-isoserine (4.0 g, 0.038 mol) in dioxane: H2O (100 mL, 1:1 v/v) at 0° C was added N-methylmorpholine (4.77 mL, 0.043 mol), followed by BoC2O (11.28 mL, 0.049 mol) and the reaction was stirred overnight with gradual warming to room temperature. Glycine (1.0 g, 0.013 mol) was then added and the reaction was stirred for 20 min. The reaction was cooled to O0C and sat aq. NaHCO3 (75 mL) was added. The aqueous layer was washed with ethyl acetate (2 x 60 mL) and then acidified to pH 1 with NaHSO4. This solution was then extracted with ethyl acetate (3 x 70 mL) and these combined organic layers were dried over Na2SO4, filtered and concentrated to dryness to give the desired N-Boc-3-ammo-2(S)-hydroxy- propanoic acid (6.30 g, 0.031 mmol, 81.5 percent yield): 1H NMR (400 MHz, CDC13) δ 7.45 (bs, 1 H), 5.28 (bs, 1 H), 4.26 (m, 1 H), 3.40-3.62 (m, 2 H), 2.09 (s, 1 H), 1.42 (s, 9 H); 13C NMR (IOO MHz, CDC13) δ 174.72, 158.17, 82, 71.85, 44.28, 28.45. N-Boc-3-amino-2(S)-hydroxy-propionic acid ; <n="62"/>To a stirring solution of S-isoserine (4.0 g, 0.038 mol) in dioxane: H2O (100 mL, 1 :1 v/v) at 0° C was added N-methylmorpholine (4.77 mL, 0.043 mol), followed by BoC2O (11.28 mL, 0.049 mol) and the reaction was stirred overnight with gradual warming to room temperature. Glycine (1.0 g, 0.013 mol) was then added and the reaction was stirred for 20 min. The reaction was cooled to 0°C and sat aq. NaHCO3 (75 mL) was added. The aqueous layer was washed with ethyl acetate (2 x 60 mL) and then acidified to pH 1 with NaHSO4. This solution was then extracted with ethyl acetate (3 x 70 mL) and these combined organic layers were dried over Na2SO4, filtered and concentrated to dryness to give the desired N-Boc-3-amino-2(5)-hydroxy- propanoic acid (6.30 g, 0.031 mmol, 81.5 percent yield): 1H NMR (400 MHz, CDC13) δ 7.45 (bs, 1 H), 5.28 (bs, 1 H), 4.26 (m, 1 H), 3.40-3.62 (m, 2 H), 2.09 (s, 1 H), 1.42 (s, 9 H); 13C NMR (100 MHz, CDC13) δ 174.72, 158.17, 82, 71.85, 44.28, 28.45.
Boc-Isoserine
Boc-L-ser(me).DCHA
L-Ser
Boc-DL-Ser(me)-OH
H-DL-Ser-OH
Boc-D-ser(me)-OH
D-Ser-OH
Boc-L-Ser(tBu)-OH
H-L-Ser(Me)-OH.HCl
Boc-D-Ser(tBu)-OH
DL-Ser(Me)-OH
Boc-D-Ser(Tbu).DCHA
D-Ser(me)
Boc-L-Ser(Bzl)-OH
H-L-Ser(tBu)-OH
Boc-DL-Ser(Bzl)-OH
D-Ser(tBu)-OH
Boc-D-Ser(Bzl)-OH
D-Ser(bzl)
Boc-L-Ser-OMe
D-Ser(bzl).HCl
Boc-DL-Ser-Ome
L-Ser(AC).Hcl
Boc-D-Ser-OMe
O-AC-Ser.Hcl
Boc-D-Ser-Oet
O-AC-L-Ser-OH
Boc-L-Ser-Obzl
H-L-Ser(Bzl)-OH.HCl
Boc-D-Ser-Obzl
H-L-Ser(Bzl)-OH
Fmoc-L-Ser-OH
H-L-Ser-OMe.HCl
Fmoc-D-Ser-OH
H-DL-Ser-OMe·HCl
Fmoc-L-Ser(tBu)-OH
H-D-Ser-OMe·HCl
Fmoc-D-Ser(tBu)-OH
L-Ser-Oet.Hcl
Fmoc-L-Ser(bzl)-OH
D-Ser-Oet.HCl
Fmoc-D-Ser(bzl)-OH
H-L-Ser-OBzl.HCl
Fmoc-L-Ser-Obzl
H-L-Ser-OBzl
Fmoc-N-Me-L-Ser(tBu)-OH
DL-Ser-Obzl.Hcl
Fmoc-N-Me-Ser(bzl)
D-Ser-Obzl.Hcl
Trt-L-Ser-Ome
D-Ser(me)-Ome.Hcl
Cbz-L-Ser-OH
H-L-Ser(tBu)-OMe
Cbz-DL-Ser
H-Ser(tBu)-OMe.HCl
Cbz-D-Ser-OH
H-D-Ser(tBu)-OMe
Cbz-L-Ser(tBu)-OH
H-D-Ser(tBu)-OMe.HCl
Z-L-Ser(Bzl)-OH
L-Ser(tbu)-Oet
Cbz-D-Ser(Bzl)-OH
L-Ser(tbu)-Oet.HCl
Cbz-L-Ser-Ome
L-Ser(tBu)-OtBu
Cbz-DL-Ser-ome
L-Ser(tbu)-Otbu.Hcl
Cbz-D-Ser-Ome
D-Ser(tbu)-otbu.hcl
Cbz-L-Ser-Obzl
H-L-Ser(Bzl)-OMe·HCl
Fmoc-L-Thr(tBu)-Ser-OH
Boc-L-Ser-OH
Boc-D-Ser-OH
Boc-L-Ser.H2O
Boc-L-ser(me)-OH
Boc-DL-Ser-OH
1. R&D service available 2. ISO certified manufacturer, quality guarantee 3.A full course of follow-up service during production 4.High cost effective 5.Quality certification documents provided per customer's request 6.Great after-sales service, maintaining close relationship with customer 7.Full resource to help decrease shipping costs 8.Free sample offered to check out quality prior to any payment 9.Payment term negotiated 10.Assit customers deal with affairs in China
Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)-; (S)-3-(tert-Butyloxycarbonylamino)-2-hydroxypropionic acid; (2S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-propanoic acid; 3-tert-ButoxycarbonylaMino-(S)-2-hydroxy-propionic acid; Boc-(S)-isoserine; (S)-3-(Boc-aMino)-2-hydroxy-propanoic acid; (S)-3-((tert-Butoxycarbonyl)aMino)-2-hydroxypropanoic acid; (2S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acidThey are usually used to pack powder. And they can prevent sunshine and water from getting bad.
The hard carton can protect your products from crashing and getting wet.
(S)-isoserine 15a (21 g, 0.20 mol) was dissolved in tetrahydrofuran (100 mL)And a mixed solvent of 10percent aqueous sodium hydroxide solution (100 mL),Di-tert-butyl dicarbonate (50 mL, 0.22 mol) was added dropwise.The reaction was carried out at room temperature for 9 hours.The aqueous phase was adjusted to pH 2 with 4 mol/L hydrochloric acid, and extracted with dichloromethane/methanol (v/v = 5/1, 50 mL × 3) and dried over anhydrous sodium sulfate.Filter by suction, concentrate under reduced pressure,The title compound 15b was obtained as a colorless oil (35 g, yield: 85percent). To a stirring solution of S-isoserine (4.0 g, 0.038 mol) in dioxane: H2O (100 mL, 1:1 v/v) at 0° C was added N-methylmorpholine (4.77 mL, 0.043 mol), followed by BoC2O (11.28 mL, 0.049 mol) and the reaction was stirred overnight with gradual warming to room temperature. Glycine (1.0 g, 0.013 mol) was then added and the reaction was stirred for 20 min. The reaction was cooled to O0C and sat aq. NaHCO3 (75 mL) was added. The aqueous layer was washed with ethyl acetate (2 x 60 mL) and then acidified to pH 1 with NaHSO4. This solution was then extracted with ethyl acetate (3 x 70 mL) and these combined organic layers were dried over Na2SO4, filtered and concentrated to dryness to give the desired N-Boc-3-ammo-2(S)-hydroxy- propanoic acid (6.30 g, 0.031 mmol, 81.5 percent yield): 1H NMR (400 MHz, CDC13) δ 7.45 (bs, 1 H), 5.28 (bs, 1 H), 4.26 (m, 1 H), 3.40-3.62 (m, 2 H), 2.09 (s, 1 H), 1.42 (s, 9 H); 13C NMR (IOO MHz, CDC13) δ 174.72, 158.17, 82, 71.85, 44.28, 28.45. N-Boc-3-amino-2(S)-hydroxy-propionic acid ; <n="62"/>To a stirring solution of S-isoserine (4.0 g, 0.038 mol) in dioxane: H2O (100 mL, 1 :1 v/v) at 0° C was added N-methylmorpholine (4.77 mL, 0.043 mol), followed by BoC2O (11.28 mL, 0.049 mol) and the reaction was stirred overnight with gradual warming to room temperature. Glycine (1.0 g, 0.013 mol) was then added and the reaction was stirred for 20 min. The reaction was cooled to 0°C and sat aq. NaHCO3 (75 mL) was added. The aqueous layer was washed with ethyl acetate (2 x 60 mL) and then acidified to pH 1 with NaHSO4. This solution was then extracted with ethyl acetate (3 x 70 mL) and these combined organic layers were dried over Na2SO4, filtered and concentrated to dryness to give the desired N-Boc-3-amino-2(5)-hydroxy- propanoic acid (6.30 g, 0.031 mmol, 81.5 percent yield): 1H NMR (400 MHz, CDC13) δ 7.45 (bs, 1 H), 5.28 (bs, 1 H), 4.26 (m, 1 H), 3.40-3.62 (m, 2 H), 2.09 (s, 1 H), 1.42 (s, 9 H); 13C NMR (100 MHz, CDC13) δ 174.72, 158.17, 82, 71.85, 44.28, 28.45.
